the 'fat' gene?

[OllieMartin]

for those that are eating lots but not gaining weight, have you seen what you're eating lots of? Or have you checked your portion sizes?

Yes, why, what should I be looking for?

[binley100]

Cakes...

[OllieMartin]

Cakes...

I've already found AND eaten all of those

[Jeanied]

I think the issue for lots of people is once the weight is put on - for whatever reason, illness, change of diet, taking up drinking too much etc. Then it is a devil to lose and it gets put back on very easily. So a genetic trigger, once tripped, cannot be turned off.

[OverWyreGrower]

OK. In theory it makes sense but what determines appetite in the first place. I have never been able to overeat. I serve small to medium portions and struggle to eat that. I enjoy food but know when I have had enough

Actually, that's a good point! I could eat a cooked breakfast, a full lunch and 3 course evening meal, and still have room for snacks, without even trying!

[janeyo]

So if you have yo-yo dieted for example, for years your body cold get kind of confused?

[janeyo]

Actually, that's a good point! I could eat a cooked breakfast, a full lunch and 3 course evening meal, and still have room for snacks, without even trying!

No I am convinced we are related... lol

[OverWyreGrower]

No I am convinced we are related... lol

Hehehehe....

[louisesgarden]

I do think the fat gene exists ! i dont diet or watch what i eat and drink and i weigh 8 1/2 stone, my daughter can eat for england ! and shes 15 5ft 7 and 7 stone ! my mum in law though is a very big lady, her daughter is the same shape plus her grandma too, my hubby although he eats less than i do, is turning into his dad, a barrel on legs, so yes i think it exists.

[Bramble_killer]

Why? Are you a geneticist? Capsid has just explained up there ^ that there is a gene that makes a difference... A quick Google turns up all sorts of interesting stuff. This is the first one I came too, but there are tons of others: Adipose gene may be the key to tackle weight

Yes, I'm a full time scientific researcher. I'm currently working on a gene that is believed to control the initial step of change when you start a high fat diet. I am also using animal models to mimic heart disease.

adipose is a gene that controls adipogenesis, which is the process of making fat cells. Every animal has fat cells. How much lipid you store in your fat cells is what makes you fat. How much you metabolise and how you metabolise is also important.

this is what your fat cells look like

[Bramble_killer]

I think the issue for lots of people is once the weight is put on - for whatever reason, illness, change of diet, taking up drinking too much etc. Then it is a devil to lose and it gets put back on very easily. So a genetic trigger, once tripped, cannot be turned off.

It's not a genetic trigger. It's a process called homeostasis. A body exists in equilibrium as such and when you put weight on, you are inducing inflammation in your body. As the weight doesn't shift, your body is now in a permanent state of inflammation. Obese people are considered to have a chronic inflammatory disease.

[Capsid]

A point about the exercise. It is useful to do some cardiovascular stimulation. The type that makes you breathe faster and heart rate increases. This is what is needed to burn that fat. But do this carefully and gradually to begin with if you are not used to it and then build it up slowly.

[Capsid]

It's not a genetic trigger. It's a process called homeostasis. A body exists in equilibrium as such and when you put weight on, you are inducing inflammation in your body. As the weight doesn't shift, your body is now in a permanent state of inflammation. Obese people are considered to have a chronic inflammatory disease.

Inflammation is an immune response What gets inflamed in obese people?

[Bramble_killer]

Inflammation is an immune response What gets inflamed in obese people?

Inflammation will cause an immune response. An inflammation caused by a pathogen is an infection.

the fat. Adipose tissue is inflammed as it's full of lipids and it starts leaking stuff out. All that attracts macrophages (the body's response system) and the macrophages start a cascade of signals that attract other macrophages to try and stem the flow.

All this eventually leads to a disorder called the metabolic syndrome including but not limited to insulin resistance, raised triglyceride levels, high blood pressure etc.

[Brengirl]

People that eat for pleasure rather than sustenance increase by pressure the stomachs capacity. It takes increasingly more food for the I'm full up button to be pushed. Anorexia is an example of the reverse. I think